The Relationship between Breast and Well-Differentiated Thyroid Cancers
Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for...
View ArticleCancer in Appalachia, 2004-2011
Background: Limited literature is available about cancer in the Appalachian Region. This is the only known analysis of all cancers for Appalachia and non-Appalachia covering 100% of the US population....
View ArticleTrends in Prostate Cancer Incidence
Background: The advent of PSA testing in the late 1980s substantially increased prostate cancer incidence rates. Concerns about overscreening and overdiagnosis subsequently led professional guidelines...
View ArticleExercise and the IGF Axis in Oncology
Exercise and physical activity have been shown to reduce the risk of many common cancers and strongly influence tumor biology. A cause–effect mechanism explaining this relationship is dependent on...
View ArticleAdolescent Vaccination Cycles
Background: Seasonality in human papillomavirus (HPV) vaccination could have a large impact on national cancer prevention efforts. We hypothesized that uptake of HPV vaccine and other adolescent...
View ArticleConsensus on Allergies and Glioma
Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory...
View ArticleDisparities in HL Survival
Background: Previous studies documented racial/ethnic and socioeconomic disparities in survival after Hodgkin lymphoma among adolescents and young adults (AYA), but did not consider the influence of...
View ArticleEndotoxins and Flagellin and Risk of Colorectal Cancer
Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as...
View ArticleSleep Insufficiency and Prostate Cancer Risk
Background: Sleep deficiency is a major public health problem. There are limited human data on whether sleep duration or disruption are risk factors for prostate cancer. Methods: We prospectively...
View ArticlePredictors of Human Papillomavirus Vaccination in Males
Background: Despite the recommendation for routine human papillomavirus (HPV) vaccination in males, coverage estimates remain low. We sought to identify predictors of receiving each HPV vaccine dose...
View ArticleTime to Colonoscopy Follow-Up
Background: To reduce colorectal cancer mortality, positive fecal blood tests must be followed by colonoscopy. Methods: We identified 62,384 individuals ages 50 to 89 years with a positive fecal blood...
View ArticleADAMTS5 Polymorphisms and AFB1-Related HCC
Background: Altered expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is observed in hepatocellular carcinoma. The genetic polymorphisms of this gene in aflatoxin...
View ArticleLifestyle Exposures and Telomere Length
Background: Telomeres protect from DNA degradation and maintain chromosomal stability. Short telomeres have been associated with an increased risk of cancer at several sites. However, there is limited...
View ArticleGeographic Factors and HPV Vaccination Initiation
Background: This study is among the first to explore geographic factors that may be associated with human papillomavirus (HPV) vaccine uptake in the United States. Methods: Data from the 2011 and 2012...
View ArticleBreast Cancer Risk Prediction Using Clinical Models and SNPs
Background: The extent to which clinical breast cancer risk prediction models can be improved by including information on known susceptibility SNPs is not known. Methods: Using 750 cases and 405...
View ArticleFamily History of Cancer and Risk of Breast Cancer Subtypes
Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting, and most studies have not assessed specific breast cancer subtypes....
View ArticleCirculating DNA and Survival in Cancer
Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA...
View ArticleArsenic Metabolism Phenotypes
Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated...
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